Globe Health Tours News

Feb 12: The concept of fatigue has undergone a steep change as the scientists at the Columbia University has succeeded in their attempt to develop a drug that is capable of minimising the fatigue arise out of tedious exercise, which will help those who are suffering with heart related ailments.

The researchers found that the fatigue after tedious exercise is due to the calcium leak inside muscle cells. They invented a drug that is capable of preventing the leaks that existed in exhausted mice. Calcium leaks are also considered as the main reason behind severe exhaustion in patients with heart related ailments. It was earlier believed that fatigue following strenuous exercise was due to accumulation of lactic acid in the muscles.

The research sheds light on to several facts, the continuous oozing of calcium inside the muscles weakens the muscle force that secrete a protein digesting enzyme that ruin the muscle fibres. Earlier the researchers at the Columbia University found that this kind of leak was found in the muscles of animals that have heart problem.

In normal circumstances the self immunity of the body will repair the damage to the muscles. At the same time the patients suffering from chronic heart failure should have to endure constant leaks that cannot be recovered by self-immunity. The test dose of the drug was given to mice after subjecting that to three weeks long swimming session. Drugs help the animal to get rid of the fatigue and were energetic even after three weeks and their muscles showed less signs of damage.

As a next step the drugs will be tested in patients with heart failure. According to British Heart Foundation 690,000 people in the UK are affected by heart failure. The outcome of this research unravels the reason behind inability of healthy muscles to withstand the fatigue of exercise that paves the way to improve function of muscle to a great deal.

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